Synthesis of 3-fluoroimidazo[1,2-a]pyrimidines and 5-fluoroimidazo[2,1-b][1,3]thiazoles via heterocyclization of (N-heteroarylimino)trifluoropyruvates |
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| Authors: | YV Rassukana PP Onys’ko AD Sinitsa |
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| Institution: | a Institute of Organic Chemistry NAS, 02094, 5 Murmanskaya St, Kyiv, Ukraine
b Oak Ridge National Laboratory, Oak Ridge, TN 37831-6242, USA |
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| Abstract: | Synthesis of 3-fluoroimidazo1,2-a]pyrimidines and 5-fluoroimidazo2,1-b]1,3]thiazoles was accomplished via triethyl phosphite-induced heterocyclization of the corresponding N-(heteroarylimino)trifluoropyruvates. This method provides a convenient approach to synthesize ring-fluorinated fused imidazoles of biological relevance. |
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| Keywords: | Fluorinated heterocycles Fluoroimidazopyrimidines Fluoroimidazothiazoles |
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