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A new general approach to 4-substituted-3-halo-2-quinolones |
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| Authors: | Shuai Zhao |
| Institution: | School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, PR China |
| Abstract: | A general procedure for the preparation of 4-substituted-3-halo-2-quinolones (halo = F, Cl, Br) utilizing 2-halo diethylphosphonoacetic acids (halo = F, Cl, Br) and o-aminophenylketones as the starting materials is described. The title compounds are obtained by an intramolecular Horner-Wadsworth-Emmons olefination of halogen-containing N-acyl-o-aminophenylketones. The transformation process is generally applicable under mild conditions. |
| Keywords: | 2-Quinolones 4-Substituted-3-fluoro-2-quinolones 4-Substituted-3-chloro-2-quinolones 4-Substituted-3-bromo-2-quinolones Horner-Wadsworth-Emmons olefination |
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