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Decarboxylative trifluoromethylation of aryl halides using well-defined copper-trifluoroacetate and -chlorodifluoroacetate precursors |
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| Authors: | Kristen A. McReynolds Laura K.G. Ackerman William W. Brennessel |
| Affiliation: | a Department of Chemistry, University of Hawaii, 2545 McCarthy Mall, Honolulu, HI 96822, United States b The X-ray Crystallographic Facility, Department of Chemistry, University of Rochester, Rochester, NY 14627, United States |
| Abstract: | New synthetic routes to (NHC)copper-trifluoroacetate and -chlorodifluoroacetate complexes were developed (NHC = N-heterocyclic carbenes) so baseline reactivity patterns could be established for the decarboxylative trifluoromethylation of organic halides. In the presence of aryl halides, loss of CO2 from these new precursors occurred at 160 °C concurrent with the formation of aryl-CF3. |
| Keywords: | Trifluoromethylation Organometallic Copper |
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