| 药物甲氧苄氨嘧啶分子模板聚合物结合作用及选择性研究 |
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| 引用本文： | 周杰 何锡文 赵 洁 史慧明. 药物甲氧苄氨嘧啶分子模板聚合物结合作用及选择性研究[J]. 高等学校化学学报, 1999, 20(2): 1-208 |
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| 作者姓名： | 周杰 何锡文 赵 洁 史慧明 |
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| 作者单位： | 南开大学化学系，吸附功能高分子材料国家重点实验室，天津，300071 |
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| 基金项目： | 国家自然科学基金(批准号:29775011)和南开大学吸附分离功能高分子材料国家重点实验室资助课题. |
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| 摘 要： | 采用分子自组装印迹技术合成了对甲氧苄氨嘧啶有高选择性的模板聚合物受体.通过Scatchard分析、
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| 关 键 词： | 分子自组装印迹技术，模板聚合物，甲氧苄氨嘧啶，底物选择性 |
| 修稿时间： | 1998-04-24 |
A Study of Binding Actionand Selectivity of TrimethoprimMolecular Template Polymer |
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| ZHOU Jie,HE XiWen,ZHAO Jie,SHI HuiMing. A Study of Binding Actionand Selectivity of TrimethoprimMolecular Template Polymer[J]. Chemical Research In Chinese Universities, 1999, 20(2): 1-208 |
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| Authors: | ZHOU Jie HE XiWen ZHAO Jie SHI HuiMing |
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| Abstract: | A molecularly templated synthetic polymer receptor highly selective for trimethoprim was prepared by a molecular selfassembly imprinting technique. The selective binding characteristics of the template polymer were evaluated by Scatchard analysis, 1H NMR study and Ultraviolet spectrometry. The results showed that a class of same binding sites, which could specificially bind to trimethoprim by cooperative hydrogen bonding, were formed in the polymer, and its dissociation constant was estimated to be 22210-4 mol/L. The selective binding experiments for substrates indicated that the polymer gave much higher affinity and selectivity for trimethoprim than for sulfanilamide and sulfapyridine. It is possiple to be a good adsorption and binding material in the selective enrichment and determination of trace trimethoprim in complex biosamples. |
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| Keywords: | Molacular selfassembly imprinting technique Template polymer Trimethoprim Substrate selectivity |
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