Direct alkylation of carboxylic in aqueous samples |
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Authors: | C A R Skow M K L Bicking |
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Institution: | (1) Department of Chemistry, SUNY-Buffalo, 14214 Buffalo, NY, USA;(2) Present address: Ecology and Environment, Inc., 195 Sugg Road, 14225 Cheektowaga, NY, USA;(3) Present address: Battelle Columbus Laboratories, 505 King Avenue, 43201 Columbus, OH, USA |
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Abstract: | Summary Carboxylic acids can be converted to their methyl esters in an aqueous sample which contains no organic solvent. The reaction
appears to be assisted by the presence of a quaternary ammonium salt surfactant. The procedure is best described as a pseudo-organic
phase, or micelle-like, reaction. The important experimental variables have been optimized by Simplex procedures. The reaction
proceeds in 80–100% yield, for common carboxylic acids, at room temperature in less than one hour. This reaction is superior
to existing two-phase extractive alkylation procedures. |
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Keywords: | Gas chromatography Alkylation Carboxylic acids Urine analysis Micelles |
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