A C-h borylation approach to suzuki-miyaura coupling of typically unstable 2-heteroaryl and polyfluorophenyl boronates |
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| Authors: | Daniel W Robbins John F Hartwig |
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| Institution: | Department of Chemistry, University of Illinois , Urbana-Champaign, Urbana, Illinois 61801, United States, and University of California , Department of Chemistry, Berkeley, California 94720, United States. |
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| Abstract: | A method for the synthesis of biaryls and heterobiaryls from arenes and haloarenes without the intermediacy of unstable boronic acids is described. Pinacol boronate esters that are analogous to unstable boronic acids are formed in high yield by iridium-catalyzed C-H borylation of heteroarenes and fluoroarenes. These boronates are stable in the solid state or in solution and can be generated and used in situ. They couple with aryl halides in the presence of simple palladium catalysts, providing a convenient route to biaryl and heteroaryl products that have been challenging to prepare via boronic acids. |
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