Solid-phase synthesis of 1,2-diheterocyclic-substituted (E)-olefins from a supported selenium resin |
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Authors: | Xu Wei-Ming Huang Xian Tang E |
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Affiliation: | Department of Chemistry and Center of Analysis and Measurement, Zhejiang University, Hangzhou 310028, P. R. China. |
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Abstract: | A library of 1,2,3-triazoles, isoxazoles, 1,2,4-oxadiazoles, and isoxazoline-containing 1,2-di-heterocyclic-substituted compounds with three points of diversity linked by an E double bond were prepared. Key steps include a 1,3-dipolar cycloaddition and Porco's two-step, one-pot condensation and alpha-alkylation reaction of selenium resins. |
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