Concise synthesis of rodgersinol and determination of the C-10 absolute configuration |
| |
Authors: | Seo Seung-Yong Jung Jong-Wha Jung Jae-Kyung Kim Nam-Jung Chin Young-Won Kim Jinwoong Suh Young-Ger |
| |
Institution: | College of Pharmacy, Seoul National University, Seoul 151-742, Korea. |
| |
Abstract: | Rodgersinol was synthesized via seven linear steps in 31% overall yield, and the absolute configuration of the C-10 stereogenic center was elucidated. The key feature of the synthesis involves the efficient Cu(II)-mediated coupling of two aromatic moieties for the diaryl ether intermediate and the enantioselective construction of the hydroxypropyl substituent by a regio- and stereoselective methyl addition to the chiral aryloxiranes in an inversion manner. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|