Efficient Cu-catalyzed asymmetric conjugate additions of alkylzinc reagents to aromatic and aliphatic acyclic nitroalkenes |
| |
| Authors: | Mampreian Dawn M Hoveyda Amir H |
| |
| Institution: | Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, MA 02467, USA. |
| |
| Abstract: | An efficient and highly enantioselective (up to 95% ee) Cu-catalyzed method for asymmetric conjugate addition (ACA) of alkylzinc reagents to acyclic disubstituted nitroalkenes is presented. Reactions are typically effected at ambient temperature in the presence of 2 mol % chiral dipeptide phosphine and 1 mol % (CuOTf)(2).C(6)H(6). Nitroalkenes bearing aromatic as well as aliphatic substituents readily undergo asymmetric additions. reaction: see text] |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
