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Water-Soluble Metalloporphyrins as Mimics of Heme-containing Enzymes |
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| Authors: | Xiao Feng LI Jian Yu LIU Zhong Xian GUO Yuan Zong LI Ai Jin HUANG Wen Bao CHANG The key laboratory of Bioorganic Chemistry and Molecular Engineering College of Chemistry and Molecular Engineering Peking University Beijing |
| Institution: | Xiao Feng LI,Jian Yu LIU,Zhong Xian GUO,Yuan Zong LI*,Ai Jin HUANG,Wen Bao CHANG The key laboratory of Bioorganic Chemistry and Molecular Engineering,College of Chemistry and Molecular Engineering,Peking University,Beijing 100871 |
| Abstract: | This letter compared catalase-, peroxidase- and cytochrome P450-like catalytic activities of 15 water-soluble metalloporphyrins produced from Fe, Mn and Co ions and 5 porphyrins. The metalloporphyrins with Fe and Mn as central ions show relatively high catalytic activities of catalase and peroxidase at pH 11.0. Only Mn-meso-tetrakis (4-N-methylpyridinium) porpho-phine of the 15 metalloporphyrins exhibits high cytochrome P450-like activity. Effects of imidazole on the catalytic reactions were also studied. |
| Keywords: | Metalloporphyrin biomimetic catalysis peroxidase catalase cytochrome P450 |
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