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A new phenanthroindolizidine alkaloid from Tylophora indica |
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| Authors: | Mini Dhiman Amit Khanna Sreedharannair L Manju |
| Institution: | 1. Special Projects Analytical Chemistry, Piramal Healthcare Ltd. 1, Goregaon (E), 400063, Mumbai, India 2. High Throughput Screening and Biotechnology, Division Nirlon Complex, Piramal Healthcare Ltd. 1, Goregaon (E), 400063, Mumbai, India 3. Organic Chemistry Division, Vellore Institute of Technology University, 632014, Vellore, India |
| Abstract: | A new phenanthroindolizidine alkaloid, 3-O-demethyl tylophorinidine (VI), was isolated from the aerial (leaves and stem) parts of Tylophora indica and characterized using different spectral techniques. Gel chromatography and reverse phase preparative HPLC were used for sample purification. The new alkaloid, VI, was screened for anticancer activity against a panel of different cancer cell lines and it showed significant anticancer activity with IC50 value in the range of 0.89?C1.40 ??M. |
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