Prototypical antipsychotic drugs protect hippocampal neuronal cultures against cell death induced by growth medium deprivation |
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| Authors: | Stéphane Bastianetto Marc Danik Françoise Mennicken Sylvain Williams Rémi Quirion |
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| Institution: | 1. Douglas Hospital Research Centre, Department of Psychiatry, McGill University, 6875 LaSalle Boulevard, Montreal, Québec, H4H 1R3, Canada
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| Abstract: | Background Several clinical studies suggested that antipsychotic-based medications could ameliorate cognitive functions impaired in certain
schizophrenic patients. Accordingly, we investigated the effects of various dopaminergic receptor antagonists – including
atypical antipsychotics that are prescribed for the treatment of schizophrenia – in a model of toxicity using cultured hippocampal
neurons, the hippocampus being a region of particular relevance to cognition. |
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