Spirobicyclo[2.2.2]octane derivatives: mimetics of baccatin III and paclitaxel (Taxol) |
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Authors: | Almqvist Fredrik Manner Sophie Thornqvist Viveca Berg Ulf Wallin Margareta Frejd Torbjorn |
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Institution: | Department of Organic Chemistry, Ume? University, Ume?, Sweden. |
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Abstract: | The formylated spirobyclic alcohol was computer modeled to be a mimetic of paclitaxel. In this model, the formyl group was used as a truncated paclitaxel side chain in order to reduce the computational work. Compound , carrying the paclitaxel side chain, was synthesized in six steps from optically active 1,3-diketone . Microtubule stabilization was not observed for , indicating that the model needs to be adjusted. |
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