热敏性印迹水凝胶的合成及对甘草酸分离性能的研究

以甘草酸分子为印迹分子，N-异丙基丙烯酰胺作为温度响应性单体，和甲基丙烯酸共同为甘草酸的吸附性单体，在大量交联剂存在下，N-甲基吡咯烷酮中经自由基模板聚合，制备了一种热敏性印迹凝胶，对水凝胶的热收缩动力学进行了表征；用红外光谱证实了甘草酸分子与单体分子间的相互作用，以旁证其模板作用的存在：同时还与没有模板作用所合成的同种凝胶作了实施对比，发现模板聚合所得的水凝胶可以富集水溶液中的甘草酸，并对它表现出特殊的选择性分离作用，分配系数约为非模板聚合水凝胶的11倍。

Synthesis of themo-sensitive imprinting hydrogels and its separation on glycyrrhizic acid

A kind of thermo-sensitive imprinting hydrogels was prepared throught the radical template polymerzation of N-isopropylacrylamide and methylacrylate in NMP with glycyrrhizic acid as the impriniting molecules,in which NIPA was the thermo-sensitive monomer,adsorbing glycyrrhizic acid together with the co-monomer MA,and a large quantity of cros -linking agent was used.The thermo-shrink kinetics of the gels were characterized and the interaction between the glycyrrhizic acid molecules and the monomer molecules was conformed through IR spectra,which could be a semi-identification for the imprinting effect.At the mean time,the separation effect of the gels on glycyrrhizic acid was compared with that of the same kind of gels polymerized without template.It was found that the former could enrich glycyrrhizic acids in the aqua solution and showed a special selective separation property,the distribution ratio being about ll times of that of the latter.