Transalkylation of N-methyl tertiary amines with 3, 4-dibromobutenolides |
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| Authors: | Meng-Xue Wei Xiao-Hui Gao Tian-Cai Li Chun-An Fan Xue-Qiang Li |
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| Institution: | a State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China;
b School of Chemistry and Chemical Engineering, Ningxia University, Yinchuan 750021, China |
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| Abstract: | The selective transalkylation of N-methyl tertiary amines with 3,4-dibromobutenolides is described. The N-methyl group of the parent tertiary amines was replaced by alkenyl units of the butenolides; and a series of butenolide-containing tertiary enamines were obtained in moderate to good yields. Interestingly, the product 2b has shown a promising anticancer activity against HeLa cell lines(IC50=0.19 μmol/L). |
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| Keywords: | Amination Enamines Butenolides Tertiary amine Transalkylation |
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