|
|||||
|
|
Neamine-heterocycle conjugates as potential anti-HIV agents |
|
| Authors: | Ri-Bai Yan Yan-Fen Wu Jun Liu Xiao-Lian Zhang Xin-Shan Ye |
| Affiliation: | a State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China;b State Key Laboratory of Virology, Department of Immunology, Hubei Province Key Laboratory of Allergy and Immunology, Wuhan University School of Medicine, Wuhan 430071, China |
| Abstract: | A series of neamine-heterocycle conjugates were designed and synthesized. All new compounds displayed more potent inhibitory effect on HIV replication than neamine, among them two compounds displayed stronger anti-HIV activity than neomycin B. The results suggested that itmight be a promising approach to modify neamine for the discovery of new anti-HIV agents. |
| Keywords: | Aminoglycoside Anti-HIV Neamine Synthesis |
| 本文献已被 ScienceDirect 等数据库收录！ | |
| 点击此处可从《中国化学快报》浏览原始摘要信息 | |
| 点击此处可从《中国化学快报》下载全文 | |