Two new guaianolide-type sesquiterpenoids from Kadsura interior

Two new guaianolide-type sesquiterpenoids, 4β,9β-dihydroxy-1α,5α-H-guaia-6,10(14)-dien (1) and 4β,9β,10α-trihydroxy-1α,5α-H-guaia-6-en (2), along with four known sesquiterpenoids (3a, 3b, 4 and 5), were isolated from Kadsura interior. Their structures and configurations were elucidated by spectroscopicmethods including 2D-NMR and HR-MS techniques. Compounds 3a and 3b were obtained as a pair of enantiomers, and their structure and absolute configuration were established from their extensive NMR spectra and by single-crystal X-ray analysis.