| An approach to the Paal–Knorr pyrroles synthesis in the presence of β-cyclodextrin in aqueous media |
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| 引用本文： | Fu-Jun Duan,Jin-Chang Ding,Hong-Juan Deng,Ding-Ben Chen,Jiu-Xi Chen,Miao-Chang Liu,Hua-Yue Wu. An approach to the Paal–Knorr pyrroles synthesis in the presence of β-cyclodextrin in aqueous media[J]. 中国化学快报, 2013, 24(9): 793-796. DOI: 10.1016/j.cclet.2013.05.012 |
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| 作者姓名： | Fu-Jun Duan Jin-Chang Ding Hong-Juan Deng Ding-Ben Chen Jiu-Xi Chen Miao-Chang Liu Hua-Yue Wu |
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| 作者单位： | College of Chemistry and Materials Engineering, Wenzhou University;Wenzhou Vocational and Technical College;College of Pharmaceutical and Chemical Engineering, Taizhou University |
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| 基金项目： | Wethank the National Natural Science Foundation of China(No. 21172175) and Natural Science Foundation of Zhejiang Province(Nos. LY12B02011 and Y4110491) for financial support. |
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| 摘 要： | An efficient and facile method for the synthesis of N-substituted pyrroles in moderate to good yields by the Paal–Knorr reaction of γ-diketones with amines in the presence of β-cyclodextrin in aqueous media has been developed.Moreover,this process tolerated diamines(e.g.,para-,meta- or orthophenylenediamine)to construct bis-pyrrole or mono-pyrrole derivates.β-Cyclodextrin can be recovered easily after the reactions and reused without evident loss in activity.
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| 关 键 词： | Pyrrole Paal–Knorr β-Cyclodextrin Water |
| 收稿时间： | 2013-03-29 |
| 修稿时间： | 2013-05-07 |
An approach to the Paal-Knorr pyrroles synthesis in the presence of β-cyclodextrin in aqueous media |
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| Fu-Jun Duan,Jin-Chang Ding,Hong-Juan Deng,Ding-Ben Chen,Jiu-Xi Chen,Miao-Chang Liu,Hua-Yue Wu. An approach to the Paal-Knorr pyrroles synthesis in the presence of β-cyclodextrin in aqueous media[J]. Chinese Chemical Letters, 2013, 24(9): 793-796. DOI: 10.1016/j.cclet.2013.05.012 |
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| Authors: | Fu-Jun Duan Jin-Chang Ding Hong-Juan Deng Ding-Ben Chen Jiu-Xi Chen Miao-Chang Liu Hua-Yue Wu |
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| Affiliation: | a College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, China;b Wenzhou Vocational and Technical College, Wenzhou 325035, China;c College of Pharmaceutical and Chemical Engineering, Taizhou University, Linhai 317000, China |
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| Abstract: | An efficient and facile method for the synthesis of N-substituted pyrroles in moderate to good yields by the Paal-Knorr reaction of γ-diketones with amines in the presence of β-cyclodextrin in aqueous media has been developed. Moreover, this process tolerated diamines(e.g., para-, meta-or ortho-phenylenediamine) to construct bis-pyrrole or mono-pyrrole derivates. β-Cyclodextrin can be recovered easily after the reactions and reused without evident loss in activity. |
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| Keywords: | Pyrrole Paal-Knorr &beta -Cyclodextrin Water |
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