|
|||||
|
|
A novel Ireland-Claisen rearrangement/Diels-Alder tandem reaction of propargylic acrylates with acyclic dienophiles |
|
| Authors: | Yun-Xia Li Yi-Lin Sheng Bi-Song Zhang |
| Institution: | College of Pharmaceutics and Material Engineering, Jinhua College of Profession and Technology, Jinhua 321007, China |
| Abstract: | A novel DABCO-catalyzed Ireland-Claisen rearrangement/Diels-Alder tandem reaction of propargylic acrylates 3 with dienophiles 4 was developed in the presence of an excess TMSCl and DBU with 1% hydroquinone as polymerization inhibitor in acetonitrile at refluxing temperature under air. This protocol gave cyclic a,b-unsaturated carboxylic acids 5 with complete regioselectivity. |
| Keywords: | Ireland-Claisen rearrangement Diels-Alder reaction Tandem reaction Propargylic acrylates |
| 本文献已被 CNKI 万方数据 ScienceDirect 等数据库收录！ | |
| 点击此处可从《中国化学快报》浏览原始摘要信息 | |
| 点击此处可从《中国化学快报》下载免费的PDF全文 | |