Synthesis and bioactivities of some new 1H-pyrazole derivatives containing an aryl sulfonate moiety |
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Authors: | Babasaheb V Kendre Mahadev G Landge Wamanrao N Jadhav Sudhakar R Bhusare |
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Institution: | Department of Chemistry, Dnyanopasak College, Parbhani 431401, MS, India |
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Abstract: | A new series of 1H-pyrazole derivatives 5a-j bearing an aryl sulfonatemoiety have been synthesized by a one-pot cyclo-condensation reaction of 2-(3-(dimethylamino)acryloyl)phenyl-4-methyl benzene sulfonates 4a-e and hydrazine hydrate or phenyl hydrazine in ethanol under reflux conditions. Some of the newly synthesized compounds were screened for their anti-inflammatory activity. All synthesized compounds were screened against Gram positive and Gram negative bacterial and fungal strains. The compound 5b was found to be a potent anti-inflammatory agent while the majority of the compounds were found to be active against microbial strains. |
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Keywords: | Pyrazole Enaminone p-Toluene sulfonyl chloride Anti-inflammatory activity COX-2 inhibitors |
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