Necessary conditions for multistationarity in discrete dynamical systems |
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Authors: | Adrien Richard Jean-Paul Comet |
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Institution: | a Laboratoire IBISC, CNRS & Université d’Evry, Boulevard François Mitterrand, 91000 Evry, France b Programme Epigénomique, 523 place des terrasses de l’Agora, 91000 Evry, France c INRIA Rhône-Alpes, 655 avenue de l’Europe, Montbonnot, 38334 Saint Ismier, France |
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Abstract: | R. Thomas conjectured, 20 years ago, that the presence of a positive circuit in the interaction graph of a dynamical system is a necessary condition for the presence of several stable states. Recently, E. Remy et al. stated and proved the conjecture for Boolean dynamical systems. Using a similar approach, we generalize the result to discrete dynamical systems, and by focusing on the asynchronous dynamics that R. Thomas used in the course of his analysis of genetic networks, we obtain a more general variant of R. Thomas’ conjecture. In this way, we get a necessary condition for genetic networks to lead to differentiation. |
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Keywords: | Discrete dynamical system Discrete Jacobian matrix Interaction graph Positive circuit Multistationarity |
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