An efficient and facile multicomponent synthesis of 4,6-diarylpyridine derivatives under solvent-free conditions |
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| Authors: | Hassan A El-Sayed Nabil H Ouf Ahmed H Moustafa |
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| Institution: | 1. Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, Egypt
2. Department of Chemistry, Faculty of Science, Tabuk University, Tabuk, Saudi Arabia
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| Abstract: | We present an efficient and facile synthesis of 4,6-diaryl-2-oxo-1,2-dihydropyridine-3-carbonitriles (5a–j) via a four-component system of aromatic aldehydes (1), acetophenones (2), ethyl cyanoacetate (3), and ammonium acetate (4). The short reaction time coupled with the simplicity of the reaction procedure and clean reaction make this method one of the most efficient methods for synthesis of this class of compounds. |
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