Ethanol and methanol induced changes in phospholipid monolayer |
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Authors: | M Weis J Jakubovský |
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Institution: | a Slovak University of Technology, Faculty of Electrical Engineering and Information Technology, Department of Physics, Bratislava, Slovakia b Comenius University, School of Medicine, Institute of Pathology, Sasinkova 4, 811 08 Bratislava, Slovakia |
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Abstract: | The main components of cell membranes are phospholipids and proteins. The aim of our study was to examine structural changes of dipalmitoyl-phosphatidylcholine (DPPC) monolayer as a simple model system of a cell membrane in different environments. Pure water, ethanol and methanol solutions were used as subphases of Langmuir films as a membrane models. For detection of changes in charge states of the molecules as well as relation with structural and conformational changes, a contactless method Maxwell's displacement currents (MDC) was used. Behaviour of DPPC molecules on two different subphases is substantialy different. In DPPC monolayer on the subphase of methanol-water, a gradual absorption (incorporation, penetration) of methanol molecules into the layer can appear. In DPPC monolayer on the subphase of ethanol-water adsorption of ethanol molecules on the layer can be observed. The membrane permeability might change. At both subphases (ethanol-water and methanol-water) the elasticity modulus of the monolayer decreases leading to the loss of membrane elasticity. |
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Keywords: | 68 08 &minus p Liquid-solid interfaces 68 18 &minus g Langmuir-Blodgett films on liquids |
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