The Kinetics of Tenoxicam Photodegradation in Solution |
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| Authors: | Sabri S. Mahmoud Mohammed A. Hassan Fayez H. El-Khatib Ayman A. Obaidat Mutaz Sheikh-Salem |
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| Affiliation: | (1) Department of Pharmaceutical Chemistry, School of Pharmacy, University of Athens, Panepistimiopolis Zografou, Athens , 15771, Greece;(2) Institute of Biology, NCSR “Demokritos” , Aghia Paraskevi, Athens, 15310, Greece; |
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| Abstract: | Photodegradation of tenoxicam was investigated under different reaction conditions. After 60 min of exposure to UV light, the photodegradation was extensive, and the maximum and minimum in the UV-visible spectrum were shifted to shorter and longer wavelengths, respectively. Ethanol exerted a photostabilizing effect on tenoxicam. Tenoxicam is more stable in acidic and basic media than in neutral solution. Increasing light intensity or temperature causes an increase in the rate of photodegradation. The photodegradation of tenoxicam was found to follow first-order kinetics under all these conditions. |
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| Keywords: | Tenoxicam photodegradation kinetics |
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