Biomimetic norfloxacin sensors made of molecularly-imprinted materials for potentiometric transduction |
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Authors: | Felismina T. C. Moreira Victor A. P. Freitas Maria G. F. Sales |
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Affiliation: | 1. REQUIMTE, Instituto Superior de Engenharia do Porto, R. Dr. Ant??nio Bernardino de Almeida, 431, 4200-072, Porto, Portugal 2. Faculdade Ci??ncias da Universidade do Porto, Rua do Campo Alegre, s/n, 4169-007, Porto, Portugal
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Abstract: | A biomimetic sensor for norfloxacin is presented that is based on host-guest interactions and potentiometric transduction. The artificial host was imprinted into polymers made from methacrylic acid and/or 2-vinyl pyridine. The resulting particles were entrapped in a plasticized poly(vinyl chloride) (PVC) matrix. The sensors exhibit near-Nernstian response in steady state evaluations, and detection limits range from 0.40 to 1.0???g?mL?1, respectively, and are independent of pH values at between 2 and 6, and 8 and 11, respectively. Good selectivity was observed over several potential interferents. In flowing media, the sensors exhibit fast response, a sensitivity of 68.2?mV per decade, a linear range from 79???M to 2.5?mM, a detection limit of 20???g?mL?1, and a stable baseline. The sensors were successfully applied to field monitoring of norfloxacin in fish samples, biological samples, and pharmaceutical products. Figure ? |
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