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Method for determination of fluoroquinolones based on the plasmonic interaction between their fluorescent terbium complexes and silver nanoparticles |
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| Authors: | Mohammad Kamruzzaman Al-Mahmnur Alam Sang Hak Lee Yeoun Suk Suh Young Ho Kim Gyu Man Kim Sung Hong Kim |
| Institution: | 1. Department of Chemistry, Kyungpook National University, Daegu, 702-701, South Korea 4. Korea Basic Science Institute Daegu Center, Daegu, 702-701, South Korea 2. Research Institute of Advanced Energy Technology, Kyungpook National University, Daegu, 702-701, South Korea 3. School of Mechanical Engineering, Kyungpook National University, Daegu, 702-701, South Korea |
| Abstract: | We report on a fluorometric method for the determination of the fluoroquinolones levofloxacin (LEV) and moxifloxacin (MOXI). It is based on the Tb(III)-sensitized luminescence that is plasmonically enhanced by silver nanoparticles (Ag NPs). The emission of the Tb(III) complexes has maximum at 545?nm after excitation at 284?nm and is strongly enhanced in the presence of the colloidal Ag NPs. Under optimum experimental conditions, luminescence intensity increases linearly with the concentration in the range from 4.16?×?10-17-3.59?×?10-15?M of LEV, and from 4.98?×?10-17-2.49?×?10-15?M for MOXI with correlation coefficients of 0.9996 and 0.9996, respectively. The limits of detection are 7.19?×?10-18?M and 8.47?×?10-18?M, respectively, and the relative standard deviations are 1.3 and 1.5% for 5 replicate measurements at 6.08?×?10-14?M of LEV and 5.48?×?10-14?M of MOXI. The method was successfully applied to the determination of LEV and MOXI in pharmaceutical samples, in urine and in serum. A new luminescent terbium(III)-fluoroquinolones (FQs) framework with silver nanoparticles exhibits a highly sensitive fluorescent response towards Tb3+ ion. The luminescence intensity of the framework was enhanced significantly by Ag NPs with the concentration of FQs which showed a good linear relationship and detection limit. |
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