Fullerene, ferrocene, chitosan and ionic liquid offer remarkable synergistic contributions towards improve electrochemical performance of DON sensor. This results that novel sensor exhibits a good repeatability (RSD=1.2%), selectivity, very low detection limit (S/N=3) of 0.0003 ng mL-1, an impedimetric response to DON in the range from 0.001 ng mL-1 to 0.3 ng mL-1 and a stability of more than 180 days. Cyclic voltammograms of, Ab/C60-FC-IL-GCE a and Ab/FC-IL-GCE b