| NMR Studies on the Subacute Biochemical Effects of Aristolochic Acid on Rat Serum |
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| 作者姓名： | XiaoYu ZHANG Hui Feng WU Xiao Jing LI Feng Kui PEI Jia Zuan NI |
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| 作者单位： | Key Laboratory of Rare Earth Chemistry and Physics, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022 |
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| 摘 要： | The subacute effect of aristolochic acid （AA） on rat serum was studied by NMR method. The biochemical effects induced by AA were characterized by an increase in the amounts of creatinine, trimethylamine N-oxide, acetoacetate, acetate and 3-D-hydroxybutyrate and lactate in serum from ^1H NMR spectra. Principal component analysis was used for further comparing the similarities of ^1H NMR spectral profiles of serum from rats treated with AA and model toxins.
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| 关 键 词： | 核磁共振 生物化学 免疫血清 老鼠 代谢物 |
| 收稿时间： | 2005-02-21 |
NMR Studies on the Subacute Biochemical Effects of Aristolochic Acid on Rat Serum |
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| XiaoYu ZHANG Hui Feng WU Xiao Jing LI Feng Kui PEI Jia Zuan NI.NMR Studies on the Subacute Biochemical Effects of Aristolochic Acid on Rat Serum[J].Chinese Chemical Letters,2005,16(11):1507-1510. |
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| Authors: | XiaoYu;ZHANG;Hui;Feng;WU;Xiao;Jing;LI;Feng;Kui;PEI;Jia;Zuan;NI |
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| Abstract: | The subacute effect of aristolochic acid (AA) on rat serum was studied by NMR method. The biochemical effects induced by AA were characterized by an increase in the amounts of creatinine, trimethylamine N-oxide, acetoacetate, acetate and 3-D-hydroxybutyrate and lactate in serum from 1H NMR spectra. Principal component analysis was used for further comparing the similarities of 1H NMR spectral profiles of serum from rats treated with AA and model toxins. |
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| Keywords: | Aristolochic acid NMR serum principal component analysis metabolite |
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