New 2-o-methylrhamno-isoflavones from Streptomyces sp |
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Authors: | Hu Jin-Feng Wunderlich Dirk Sattler Isabel Thiericke Ralf Grabley Susanne Feng Xiao-Zhang |
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Institution: | Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Xian Nong Tan Street, Beijing 100050, P. R. China. |
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Abstract: | Chemical screening with extracts of Actinomycetes strains resulted in the detection, isolation and structure elucidation of five new isoflavone glycosides from Streptomyces sp. (GT 51173): 5-O-alpha-L-rhamnopyranosyl genestein (genestein G1, 1), 5-O-alpha-L-rhamnopyranosyl-7-O-2-O-(methyl)-alpha-L-rhamnopyranosyl] genestein (genestein G2, 2), 7,4'-O-di-2-O-(methyl)-alpha-L-rhamnopyranosyl] daidzein (daidzein G1, 3), 6-O-methyl-7-O-2-O-(methyl)-alpha-L-rhamnopyranosyl] daidzein (daidzein G2, 4) and 7-O-2-O-(methyl)-alpha-L-rhamnopyranosyl] daidzein (daidzein G3, 5). As a striking structural feature, 2-5 bear one or two alpha-L-rhamnopyranosyl sugar moieties with methoxy groups in an axial position at C-2. |
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