Cyanovirin-N binding to Manalpha1-2Man functionalized dendrimers |
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| Authors: | Mangold Shane L Morgan Joel R Strohmeyer Gregory C Gronenborn Angela M Cloninger Mary J |
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| Institution: | Department of Chemistry and Biochemistry and Center for Bioinspired Nanomaterials, 108 Gaines Hall, Montana State University, Bozeman, MT 59717, USA. |
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| Abstract: | Manalpha1-2Man functionalized G(3) and G(4)-PAMAM dendrimers have been synthesized and characterized by MALDI-TOF MS and NMR spectroscopy. Precipitation assays to assess the binding of the dimannose-functionalized dendrimers to Cyanovirin-N, a HIV-inactivating protein that blocks virus-to-cell fusion through high mannose mediated interactions, are presented. |
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