CD40mAb adjuvant induces a rapid antibody response that may be beneficial in post-exposure prophylaxis |
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| Authors: | Vijay NS Bhagawati-Prasad Evy De Leenheer Nadine P Keefe Lorna A Ryan Jennifer Carlring Andrew W Heath |
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| Affiliation: | (1) Department of Infection and Immunity, University of Sheffield Medical School, Beech Hill Rd, S10 2RX Sheffield, UK;(2) Adjuvantix Ltd, c/o Fusion plc, Sheffield Bioincubator, Leavygreave Rd, Sheffield, UK |
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| Abstract: | Active vaccination can be effective as a post-exposure prophylaxis, but the rapidity of the immune response induced, relative to the incubation time of the pathogen, is critical. We show here that CD40mAb conjugated to antigen induces a more rapid specific antibody response than currently used immunological adjuvants, alum and monophosphoryl lipid A™. |
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