In vivo assessment of dynamics of various elements in living rat by using a multitracer |
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| Authors: | K. Matsumoto I. Ui R. Hirunuma S. Enomoto K. Endo |
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| Affiliation: | (1) Department Physical Chemistry, Showa Pharmaceutical University, 3-3165 Higashi-Tamagawagakuen, Machida, Tokyo, 149-8543, Japan;(2) Division of Radioisotope Technology, Cyclotron Center, RIKEN (The Institute of Physical and Chemical Research), 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan;(3) Department Physical Chemistry, Showa Pharmaceutical University, 3-3165 Higashi-Tamagawagakuen, Machida, Tokyo, 149-8543, Japan |
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| Abstract: | Time series of the distribution of bio-trace elements in the upper abdomen of living rats were examined using the in vivo multitracer analysis technique. The in vivo dynamics of the elements were estimated by comparison with the distribution of 74As. Vanadium, Mn, Fe, Co, Zn, Se, and Rb were distributed in tissues of the upper abdomen, i.e., mainly in the liver. Be, Sr, and Y might be in the blood or bone at a low level and in the excretion stage already. Dynamics of bio-trace elements were noninvasively obtained in a living rat within one hour after administration. |
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