硅胶支载稀土氯化钐一步催化合成多取代Mannich碱

采用硅胶与稀土氯化钐在甲苯或四氯化碳中反应，制备了硅胶支载稀土氯化钐. 与已报道的支载型催化剂相比，所制备的硅胶支载稀土氯化钐作为催化剂具有支载量稳定、催化反应时间短、产率高和选择性强等优点，同时催化反应条件温和、操作简便、不污染环境且催化剂重复利用率高. 室温条件下，以硅胶支载稀土氯化钐作为催化剂催化对甲氧基苯乙酮、芳香醛和芳香胺的三组分体系，利用“一锅法”合成了28种新的β-氨基酮类化合物，并探索了不同反应条件对产率的影响. 催化剂经过IR和XRD表征，催化反应产物通过IR、¹H NMR和元素分析确定.

Synthesis of Multiaryl-substituted Mannich Base Catalysed by Silica-supported Rare Earth Samarium Chloride

Many supported-catalysts are applied to the Mannich reaction, but they have disadvantages of low yield, unstability of supported rate and asking for long time. Silica-supported rare earth samarium chloride(SiO₂-OSmCl₂) was prepared by the reaction of silica and rare earth samarium chloride in toluene or CCl₄. The effects of different reaction conditions on the yields were investigated. This protocol has advantages of stability of supported rate, short time, mild condition, high yield, high selectivity, simple work-up, environmental friendly procedure and the catalyst can be reused. The three components of p-methoxyacetophenone, aromatic aldehydes and aromatic amines were reacted by one-pot Mannich reaction and catalysed by SiO₂-OSmCl₂ in ethanol at room temperature. As results, a series of new β-Amino carbonyl compounds were synthesized. The catalyst was characterized via IR and XRD, simultaneously the products were determined by IR, ¹H NMR and elemental analysis.