| 共同装载吴茱萸碱和Fe3O4纳米粒子的磁性药物载体的制备 |
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| 引用本文： | 王岩,王笑英,吕言云,许文彬,郭轶,徐力.共同装载吴茱萸碱和Fe3O4纳米粒子的磁性药物载体的制备[J].高等学校化学学报,2013,34(12):2866. |
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| 作者姓名： | 王岩 王笑英 吕言云 许文彬 郭轶 徐力 |
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| 作者单位： | 1. 吉林大学分子酶学工程教育部重点实验室, 长春 130012;
2. 吉林省人民医院, 长春 130021;
3. 吉林大学艾滋病疫苗国家工程实验室,;
4. 生命科学学院, 长春 130012 |
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| 基金项目： | 国家自然科学基金（批准号：81271697，30970719）；吉林省科委重点科技攻关项目（批准号：20130206069GX）；高等学校博士学科点专项科研基金（批准号：20100061120077，20120061110021）和中国博士后科学基金（批准号：20100481048）资助. |
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| 摘 要： | 以单甲醚-聚乙二醇-聚（丙交酯-乙交酯）（mPEG-PLGA）作为载体，采用溶液透析的方法共同装载抗癌药物吴茱萸碱和Fe3O4 磁性纳米粒子. 通过透射电子显微镜、红外光谱、紫外-可见光谱及体外释放实验、普鲁士蓝染色、体外毒性实验和磁靶向研究，综合评价了磁性纳米药物载体的性能. 结果表明，磁性药物载体胶束分散性良好，粒径均一，有较高的载药量和包封率，能够实现药物缓释，具有磁靶向特性.
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| 关 键 词： | 磁性纳米粒子 聚乙二醇/聚丙交酯-乙交酯 吴茱萸碱 缓释 磁靶向特性 |
| 收稿时间： | 2013-08-19 |
Preparation of Magnetic Drug Carriers with Evodiamine and Fe3O4 Nanoparticles Co-encapsulated |
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| WANG Yan,WANG Xiao-Ying,LV Yan-Yun,XU Wen-Bin,GUO Yi,XU Li.Preparation of Magnetic Drug Carriers with Evodiamine and Fe3O4 Nanoparticles Co-encapsulated[J].Chemical Research In Chinese Universities,2013,34(12):2866. |
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| Authors: | WANG Yan WANG Xiao-Ying LV Yan-Yun XU Wen-Bin GUO Yi XU Li |
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| Institution: | 1. Key Laboratory for Molecular Enzymolozy and Engineering, Ministry of Education, Jilin University, Changchun 130012, China;
2. Jilin Province People's Hospital, Changchun 130021, China;
3. National Engineering Laboratory for Aids Vaccine,;
4. School of Life Science, Jilin University, Changchun 130012, China |
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| Abstract: | Evodiamine and Fe3O4 nanoparticles were co-encapsulated by dialysis method with methoxy poly(ethylene glycol)/poly(lactide-co-glycolide)(mPEG-PLGA) as carriers. The magnetic drug carriers were characterized through transmission electron microscope(TEM), Fourier transform infrared spectrum(FTIR), UV-Vis spectrum(UV), in vitro release action, Prussian blue staining, in vitro cytotoxicity and magnetic targeting study. The data suggested that Fe3O4 nanoparticles and drug loaded micelles were spherical morphology with narrow size distribution, and had high entrapment capacity with slow release in vitro release profiles. Furthermore, the Fe3O4 nanoparticles and drug loaded micelles were safe and had magnetic targeting properties. |
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| Keywords: | Magnetic nanoparticle Poly(ethylene glycol)/poly(lactide-co-glycolide)(mPEG-PLGA) Evodiamine Sustained-release Magnetic targeting property |
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