Quinazolines 1. Synthesis and chemical reactions of 6-chlorosulfonyl-quinazoline-2,4-diones |
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| Authors: | R. Sh. Kuryazov N. S. Mukhamedov Kh. M. Shakhidoyatov |
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| Affiliation: | (1) S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences Republic of Uzbekistan, Tashkent, 700170, Uzbekistan |
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| Abstract: | Treatment of quinazoline-2,4-dione and its symmetrical 1,3-dialkyl derivatives with chlorosulfonic acid gave the corresponding 6-chlorosulfonylquinazoline-2,4-diones. Reaction of the compounds obtained with nucleophilic agents (water, ammonia, aliphatic and cyclic amines) gave the corresponding free 2,4-dioxoquinazoline-6-sulfonic acids, 6-sulfamidoquinazoline-2,4-diones, and 2,4-dioxoquinazoline-6-sulfonic acid amides. __________ Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 420–427, March 2008. |
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| Keywords: | 2,4-dioxoquinazoline-6-sulfonic acid amides 2,4-dioxoquinazoline-6-sulfonic acids symmetrical 1,3-dialkylquinazoline-2,4-diones 6-chlorosulfonylquinazoline-2,4-diones nucleophilic and electrophilic substitution |
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