气相色谱-离子阱质谱联用测定玩具中8种酯类致敏性芳香剂

建立了气相色谱-离子阱质谱联用测定玩具中丙烯酸乙酯等8种酯类致敏性芳香剂的方法。对于布绒和贴纸玩具样品,采用丙酮超声提取20 min后过0.45μm滤膜直接进样,对于塑料玩具样品,经相应溶剂提取,离心后,澄清溶液经Envi-carb石墨化碳固相萃取小柱净化,丙酮定容,过0.45μm滤膜后通过30 m HP-5 MS色谱柱分离,质谱进行检测,外标法定量。方法对于不同物质的定量限(LOQ)在0.05～8.0 mg/kg之间,线性范围为0.005～50 mg/L,在3个添加水平的平均回收率在80.2%～105.9%之间,RSD在0.7%～8.9%之间。该方法可用于玩具中丙烯酸乙酯等8种酯类致敏性芳香剂的检测。

Determination of 8 ester fragrance allergens in toys by gas chromatography-ion trap mass spectrometry

A gas chromatography-ion trap mass spectrometric(GC-IT-MS/MS) method was developed for the determination of 8 ester fragrance allergens in toys.The experimental conditions,such as sample pretreatment conditions,and the analytical conditions of GC-IT-MS/MS,were optimized.Paster toy and plush toy samples were extracted by acetone,determined by GC-IT-MS/MS.Plastic toy samples were extracted by corresponding solvents.After being centrifuged the clarified solution was concentrated through Envi-carb SPE column,and the concentration was determined by GC-IT-MS/MS and quantified by external standard method.The linear ranges were 0.005-50 mg/L and the limits of quantification were 0.05 mg/kg-8.0 mg/kg.Results of tests for recovery and precision at 3 concentration levels were found in the ranges of 80.2%~105.9% and(RSDs)0.7%~8.9%,respectively.The method is accurate and sensitive,which can be applied to the analysis of 8 ester fragrance allergens in toys.