| Abstract: | The λ-Radiolysis reactions of mitomycin C ( 1 ) and its derivatives were studied in the hope of developing a radiation-induced drug (RID). The λ-radiolysis reactions were carried out in aqueous solutions under the condition where hydrated electron (e?aq) was generated as a principal reactive species. The competitive λ-radiolysis studies revealed that the rate constants for the reactions of 1 with e?aq at room temperature was 3.6 × 1010 dm3 mol?1s?1. Among mitomycin C derivatives, the 5H-6-alkoxyimino derivatives 11 and 12 , and compound 13 in which ring A of 1 has the 4-hydroxy-6-hydroxyimino structure cleaved to give 1 . The mechanic aspect of these λ-radiolysis reactions is discussed. |
