Synthesis of Cationic Cholesterol Derivatives with Fragments of Aliphatic Nitrogen-Containing Bases |
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| Authors: | Sokolova T V Klesareva Yu S Serebrennikova G A |
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| Institution: | (1) Lomonosov Moscow State Academy of Fine Chemical Technology, pr. Vernadskogo 86, Moscow, 119571, Russia |
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| Abstract: | Cationic cholesterol derivatives were synthesized, in which fragments of aliphatic amines (2-di-methylaminoethanol, N,N-dimethylethylenediamine, and N,N,N',N'-tetramethylethylenediamine) are attached to the cholesterol backbone either directly or through a spacer ester or carbamate moiety. The products may be used as efficient agents for liposome-mediated transfection. |
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