Substituted guanidines: introducing diversity in combinatorial chemistry |
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| Authors: | del Fresno M El-Faham A Carpino L A Royo M Albericio F |
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| Institution: | Departament de Química Orgànica, Universitat de Barcelona, 08028 Barcelona, Spain. |
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| Abstract: | The guanidine moiety is an important motif present in many biologically active compounds. Fully substituted guanidines are of key importance for the development of bioactive molecules. The present paper reports on an efficient procedure for the direct solid-phase conversion of amines to fully substituted guanidines under very mild conditions. |
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