A new three-carbon synthon for efficient synthesis of benzannelated and 1-(2-arylethenyl) heterocycles |
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| Authors: | Katritzky Tymoshenko Monteux Vvedensky Nikonov Cooper Deshpande |
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| Institution: | Center for Heterocyclic Compounds, University of Florida, Department of Chemistry, Gainesville, Florida 32611-7200, Bristol Myers Squibb Co., Pharmaceutical Research Institute, Route 206 & Provinceline Road, Princeton, New Jersey 08563, and Bristol. |
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| Abstract: | The novel three-carbon synthon 1-(1H-1,2, 3-benzotriazol-1-yl)-3-chloroacetone for the synthesis of benzothiazoles, pyrido1,2-a]indoles, and styryl-substituted indolizines and imidazo1,2-a]pyridines is reported. The proposed routes are a general and efficient approach for heterocyclizations followed by benzannelations or attachment of arylethenyl pharmacophores. |
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