Synthesis of tri- and tetrasubstituted furans catalyzed by trifluoroacetic acid |
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| Authors: | Stauffer Neier |
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| Institution: | Institute of Chemistry, University of Neuchatel, Avenue de Bellevaux 51, CH-2007 Neuchatel, Switzerland. |
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| Abstract: | Substituted 2-hydroxy-3-acetylfurans are synthesized by alkylation of tert-butyl acetoacetate with an alpha-haloketone followed by treatment of the obtained intermediate with trifluoroacetic acid (TFA). A second alkylation of the intermediate followed by treatment with trifluoroacetic acid provides access to disubstituted 2-methylfurans. |
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