Hybrid macromolecular antioxidants based on hydrophilic polymers and sterically hindered phenols |
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| Authors: | D V Aref’ev I S Belostotskaya V B Vol’eva N S Domnina N L Komissarova O Yu Sergeeva R S Khrustaleva |
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| Institution: | (1) Department of Chemistry, St. Petersburg State University, 26 Universitetskii prosp., St. Peterhoff, 198504 St. Petersburg, Russian Federation;(2) N. M. Emanuel’ Institute, Russian Academy of Sciences, 4 ul. Kosygina, 119991 Moscow, Russian Federation;(3) V. A. Almazov Research Institute of Cardiology, Ministry of Public Health and Social Development of the Russian Federation, 15 ul. Parkhomenko, 194156 St. Petersburg, Russian Federation |
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| Abstract: | A novel class of biologically active substances was created. These are hybrid macromolecular antioxidants (HMAO) based on
hydrophilic polymers with chemically grafted sterically hindered phenols with different structural parameters. The antiradical
activities of HMAO were assessed in reactions with 2,2-diphenyl-1-picrylhydrazyl and the corresponding sodium sulfonate in
various solvents. The mechanism that explains the substantially enhanced activities of HMAO in water was proposed. The state
of HMAO in solutions was studied by viscosimetry and photon correlation spectroscopy. HMAO were assayed in biological models.
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 4, pp. 751–760, April, 2007. |
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| Keywords: | hybrid bioantioxidants sterically hindered phenols hydrophilic polymers antiradical activity mechanism aggregates hydrodynamic properties plasma substitutes |
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