3-取代-3-苯基-1-茚酮类化合物的合成

以3-苯基-1-茚酮（1）为原料，THF为溶剂，二异丙基氨基锂（LDA）为碱，与碘代烷（RI）经亲核取代反应合成了4个3-取代-3-苯基-1-茚酮类化合物（3a~3d)，其中3b~3d为新化合物，其结构经¹H NMR， ¹³C NMR 和EI-GC-MS表征。在最佳反应条件［1 1.0 eq., LDA/RI=2.1/1.5（当量比）,于0 ℃~rt反应5 h］下，3a~3d收率为70％～80％。

Synthesis of 3-Substituted-3-phenyl-1-indanone Compounds

Four 3-substituted-3-phenyl-1-indanone compounds（3a~3d, 3b~3d were novel compounds） were synthesized by nucleophilic substitution reaction of 3-phenyl-1-indanone（1） with iodides（RI）， using LDA as base and THF as solvent. The structures were characterized by ¹H NMR， ¹³C NMR and EI-GC-MS． The yield of 3a~3d were 70％～80％ under the optimum reaction conditions（1 1.0 eq., LDA/RI=2.1/1.5, at 0 ℃~rt for 5 h）.