Three-component synthesis of functionalized 5-oxo-4,5-dihydroindeno[1,2-b]pyrans |
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| Authors: | Issa Yavari Mehdi Sirouspour Sanaz Souri |
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| Affiliation: | (1) Chemistry Department, Tarbiat Modarres University, PO Box 14115-175, Tehran, Iran |
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| Abstract: | Summary Protonation of the reactive intermediates produced in the reaction between alkyl(aryl) isocyanides and dialkyl acetylenedicarboxylates by indan-1,3-dione leads to vinylnitrilium cations, which undergo carbon centered Michael type addition with the conjugate base of the CH-acid to produce functionalized 5-oxo-4,5-dihydroindeno[1,2-b]pyrans. |
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| Keywords: | isocyanides three-component reaction indan-1,3-dione Ugi reaction acetylenic ester hindered rotation |
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