Synthesis and cholera toxin binding properties of a lactose-2-aminothiazoline conjugate |
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| Authors: | Vrasidas Ioannis Kemmink Johan Liskamp Rob M J Pieters Roland J |
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| Affiliation: | Department of Medicinal Chemistry, Utrecht Institute of Pharmaceutical Sciences, Utrecht University, P.O. Box 80082, 3508 TB, The Netherlands. |
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| Abstract: | [structure: see text] During the search for improved monovalent ligands for cholera toxin (CT), a new lactose-2-aminothiazoline conjugate was discovered. In a fluorescence binding assay the compound was found to be one of the strongest relatively simple CT ligands to date with a K(d) of 23 microM. |
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