First direct lithiation of 2-pyridylpiperazine on solid phase |
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| Authors: | Gros Philippe Louërat Frédéric Fort Yves |
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| Institution: | Synthèse Organique et Réactivité, UMR CNRS-UHP 7565, Faculté des Sciences, Université Henri Poincaré-Nancy I, BP 239, 54506, Vandoeuvre-Lès-Nancy, France. philippe.gros@sor.uhp-nancy.fr |
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| Abstract: | reaction: see text] The first direct lithiation of a pyridine derivative on solid phase has been realized. Metalation of polymer-bound 2-pyridylpiperazine with the BuLi-LiDMAE reagent followed by electrophilic quenching and subsequent cleavage provided a range of new useful C-6 substituted 2-piperazinylpyridines. |
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