首页 | 本学科首页   官方微博 | 高级检索  
     检索      


Enantioselective Synthesis of Chiral Carboxylic Acids from Alkynes and Formic Acid by Nickel-Catalyzed Cascade Reactions: Facile Synthesis of Profens
Authors:Peng Yang  Yaxin Sun  Kaiyue Fu  Li Zhang  Guang Yang  Jieyu Yue  Yu Ma  Jianrong Steve Zhou  Bo Tang
Abstract:We report a stereoselective conversion of terminal alkynes to α-chiral carboxylic acids using a nickel-catalyzed domino hydrocarboxylation-transfer hydrogenation reaction. A simple nickel/BenzP* catalyst displayed high activity in both steps of regioselective hydrocarboxylation of alkynes and subsequent asymmetric transfer hydrogenation. The reaction was successfully applied in enantioselective preparation of three nonsteroidal anti-inflammatory profens (>90 % ees) and the chiral fragment of AZD2716.
Keywords:cascade reaction  chiral carboxylic acid  hydrocarboxylation  Nickel  transfer hydrogenation
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号