2,2,2‐Trifluoroacetophenone as an Organocatalyst for the Oxidation of Tertiary Amines and Azines to N‐Oxides |
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| Authors: | Dimitris Limnios Dr Christoforos G Kokotos |
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| Institution: | Laboratory of Organic Chemistry, Department of Chemistry, University of Athens, Panepistimiopolis 15771, Athens (Greece), Fax: (+30)?2107274761 |
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| Abstract: | A cheap, mild and environmentally friendly oxidation of tertiary amines and azines to the corresponding N‐oxides is reported by using polyfluoroalkyl ketones as efficient organocatalysts. 2,2,2‐Trifluoroacetophenone was identified as the optimum catalyst for the oxidation of aliphatic tertiary amines and azines. This oxidation is chemoselective and proceeds in high‐to‐quantitative yields utilizing 10 mol % of the catalyst and H2O2 as the oxidant. |
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| Keywords: | green chemistry hydrogen peroxide N‐oxides organocatalysis oxidation |
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