Direct Arylation of N‐Heteroarenes with Aryldiazonium Salts by Photoredox Catalysis in Water |
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| Authors: | Prof. Dr. Dong Xue Zhi‐Hui Jia Cong‐Jun Zhao Yan‐Yan Zhang Prof. Dr. Chao Wang Prof. Dr. Jianliang Xiao |
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| Affiliation: | 1. Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an 710062 (China);2. Liverpool Centre for Materials and Catalysis, University of Liverpool, Liverpool, L69 7ZD (UK) |
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| Abstract: | A highly effective visible light‐promoted “radical‐type” coupling of N‐heteroarenes with aryldiazonium salts in water has been developed. The reaction proceeds at room temperature with [Ru(bpy)3]Cl2 ? 6 H2O as a photosensitizer and a commercial household light bulb as a light source. Pyridine and a variety of substituted pyridines are effective substrates under these reaction conditions, and only monosubstituted products are formed with different regioselectivities. Using aqueous formic acid as solvent, an array of xanthenes, thiazole, pyrazine, and pyridazine are compatible with this new arylation approach. The broad substrate scope, mild reaction conditions, and use of water as reaction solvent make this procedure a practical and environmentally friendly method for the synthesis of compounds containing aryl‐heteroaryl motifs. |
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| Keywords: | aryldiazonium salts cross‐coupling green chemistry N‐heteroarenes photoredox catalysis water |
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