Fluorescent Probes Based on Nucleophilic Substitution–Cyclization for Hydrogen Sulfide Detection and Bioimaging |
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| Authors: | Bo Peng Dr Wei Chen Dr Chunrong Liu Ethan W Rosser Armando Pacheco Yu Zhao Prof Hector C Aguilar Prof Ming Xian |
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| Institution: | 1. Department of Chemistry, Washington State University, Pullman, WA 99164 (USA), Fax: (+1)?509‐335‐8867;2. Paul?G. Allen School for Global Animal Health, Washington State University, Pullman, WA 99164 (USA) |
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| Abstract: | The design, synthesis, properties, and cell imaging applications of a series of 2‐pyridyl disulfide based fluorescent probes (WSP1, WSP2, WSP3, WSP4 and WSP5) for hydrogen sulfide detection are reported. The strategy is based on the dual‐nucleophilicity of hydrogen sulfide. A hydrogen sulfide mediated tandem nucleophilic substitution‐cyclization reaction is used to release the fluorophores and turn on the fluorescence. The probes showed high sensitivity and selectivity for hydrogen sulfide over other reactive sulfur species, including cysteine and glutathione. |
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| Keywords: | cell imaging cyclization fluorescence fluorescent probes hydrogen sulfide |
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